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KMID : 0104920210300020033
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Journal of Hawhwa Medicine
2021 Volume.30 No. 2 p.33 ~ p.40
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A Study on the Availability of Functional Materials for Inflammatory Response Improvement of Cinnamomum cassia Presl and Rehmannia glutinosa Liboschitz Complex
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Choi Hyeon-Min
Kim Dong-Hee
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Abstract
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This study was conducted to suggest the Cinnamomum cassia Presl and Rehmannia glutinosa Liboschitz Complex (CRC) possibility of use as a functional natural material for improved inflammatory response.
Cinnamomum cassia Presl and Rehmannia glutinosa Liboschitz were mixed in a 2:1 ratio, extracted with hot water, and then powdered and used in the study. After, the cytotoxicity of CRC for RAW264.7 cell were evaluated by MTT assay, the anti-inflammatory effect in macrophages was evaluated by ELISA, qRT-PCR, and western blot assay. CRC did not proliferate macrophages but decreased nitric oxide and prostaglandin E2 production in LPS-induced RAW264.7 cell. Also,
decreased NOS2 and PTGS2 gene expression, and ERK, JNK, and p38 protein phosphorylation in a concentration-dependent manner. As a result, CRC have regulated the production and expression of inflammatory cytokines in LPS-induced RAW264.7 cell. Therefore, it is thought that CRC can be used as a functional natural material that improving nflammatory response.
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KEYWORD
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Anti-inflammatory, Cinnamomum cassia Presl, Rehmannia glutinosa Liboschitz, NSAIDs, functional m
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